SHP2-IN-26
SHP2-IN-26 (Compound 4b) is a highly selective SHP2 allosteric inhibitor with a IC50 value of 3.2 nM. SHP2-IN-26 inhibits the phosphorylation of ERK and AKT in NCI-H358 cells. SHP2-IN-26 has antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Phosphatase; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-in-26.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]1[C@H](C)OCC12CCN(C3=CN=C4C(NN=C4SC5=CC=CC(Cl)=C5Cl)=N3)CC2
Molecular Formula
C20H22Cl2N6OS
Molecular Weight
465.40
References & Citations
[1]Xu W Q, et al. Discovery of 1H-pyrazolo [3, 4-b] pyrazine derivatives as selective allosteric inhibitor of protein tyrosine phosphatase SHP2 for the treatment of KRASG12C-mutant non-small cell lung cancer. Journal of Biomolecular Structure and Dynamics, 2024: 1-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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