RI-STAD-2
RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA) . RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer[1].
Product Specifications
UNSPSC
12352209
Target
PKA
Type
Peptides
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ri-stad-2.html
Solubility
10 mM in DMSO
Smiles
O=C([C@](NC1=O)(C)CCC/C=C/CCC[C@](C(N[C@H](C(N[C@H](C(N[C@H]1C)=O)CC2=CC=C(O)C=C2)=O)CCC(N)=O)=O)(C)NC([C@@H](NC(COCCOCCOCCN)=O)CC(C)C)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCC(O)=O)=O)[C@@H](C)O)=O)C)=O)CCC(O)=O)=O)CCCCN)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC(N)=O)=O)CC(O)=O)=O)C)=O)CC(C)C)=O)CCC(N)=O
Molecular Formula
C109H181N25O35
Molecular Weight
2401.75
References & Citations
[1]Autenrieth K, et al. Defining A‐kinase anchoring protein (AKAP) specificity for the protein kinase A subunit RI (PKA‐RI) [J]. Chembiochem, 2016, 17 (8) : 693-697.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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