Risedronic acid-d4

Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid (HY-B0148) . Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC50 of 20.3 μM) [1][2][3][4].

Product Specifications

CAS Number

[1035438-80-2]

Product Name Alternative

Risedronate-d4

UNSPSC

12352005

Target

Apoptosis; Isotope-Labeled Compounds; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Others

Field of Research

Cancer; Infection; Metabolic Disease

Solubility

10 mM in DMSO

Smiles

C(CC=1C(=C(C(=NC1[2H])[2H])[2H])[2H])(P(=O)(O)O)(P(=O)(O)O)O

Molecular Formula

C7H7D4NO7P2

Molecular Weight

287.14

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Fujita H, et al. Effect of risedronate on osteoblast differentiation, expression of receptor activator of NF-κB ligand and apoptosis in mesenchymal stem cells. Basic Clin Pharmacol Toxicol. 2011 Aug;109 (2) :78-84. |[3]Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55 (5) :2026-31.