YAP/TAZ-TEAD-IN-2
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that inhibits the interaction between YAP/TAZ and TEAD. YAP/TAZ-TEAD-IN-2 suppresses the transcriptional activity of TEAD, with an IC50 of 1.2 nM. YAP/TAZ-TEAD-IN-2 inhibits YAP/TAZ-TEAD target genes expression (Cyr61, CTGF, AXL and Survivin) and breast cancer cell proliferation[1].
Product Specifications
UNSPSC
12352211
Target
Survivin; TAM Receptor; YAP
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yap-taz-tead-in-2.html
Smiles
O=S(NCCN(C=C1)C(C1=C2)=CC=C2OCC3=CC=CC=C3)(C=C)=O
Molecular Formula
C19H20N2O3S
Molecular Weight
356.44
References & Citations
[1]Toulotte, et al. Towards the design of ligands of the internal pocket TEADs C-terminal domain. European journal of medicinal chemistry, 2025, 282, 117026.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YAP/TAZ-TEAD
Frequently Asked Questions
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