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Cromolyn (disodium) (Standard)

Cromolyn disodium (Standard) (Cromoglycate disodium (Standard) ) is the analytical standard of Cromolyn disodium. This product is intended for research and analytical applications. Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects[1][2][3].

Product Specifications

CAS Number

15826-37-6

Product Name Alternative

Cromoglycate (disodium) (Standard) ; Cromoglicic acid (disodium) (Standard) ; FPL-670 (Standard)

UNSPSC

12352005

Target

Amyloid-β; GSK-3; NF-κB; Reference Standards

Type

Reference Standards

Related Pathways

Neuronal Signaling; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cromolyn-sodium-standard.html

Purity

99.84

Smiles

OC(COC1=C2C(C=C(OC2=CC=C1)C(O[Na])=O)=O)COC3=C4C(C=C(OC4=CC=C3)C(O[Na])=O)=O

Molecular Formula

C23H14Na2O11

Molecular Weight

512.33

References & Citations

[1]Gan, X., et al., Treatment of mice with cromolyn sodium after reperfusion, but not prior to ischemia, attenuates small intestinal ischemia-reperfusion injury. Mol Med Rep, 2013. 8 (3) : p. 928-34.|[2]Ng, G. and A. Ohlsson, Cromolyn sodium for the prevention of chronic lung disease in preterm infants. Cochrane Database Syst Rev, 2012. 6: p. CD003059.|[3]Huang L, et al. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling. Pharmacol Res. 2017 Aug 31. pii: S1043-6618 (17) 30796-X.

Shipping Conditions

Room Temperature

Storage Conditions

4°C, sealed storage, away from light and moisture, under nitrogen

Scientific Category

Reference Standards

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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