KUS121
KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress[1][2].
Product Specifications
CAS Number
1357164-52-3
UNSPSC
12352005
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kus121.html
Purity
99.76
Solubility
DMSO : 58.33 mg/mL (ultrasonic)
Smiles
O=S(C1=C2C=CC=CC2=C(N)C(/N=N/C3=CC=C(C4=CC=C(C=C4C)F)N=C3)=C1)(O[Na])=O
Molecular Formula
C22H16FN4NaO3S
Molecular Weight
458.44
References & Citations
[1]KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress. Sci Rep. 2017 Mar 20:7:44873.|[2]Hisanori Kinoshita, et al. KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion. Sci Rep. 2019 Aug 8;9 (1) :11519.|[3]Tomoko Hasegawa, et al. Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration. Sci Rep. 2016 Aug 9:6:31184.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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