Cleistanthin B

Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 μM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].

Product Specifications

CAS Number

[30021-77-3]

Product Name Alternative

Diphyllin O-glucoside

UNSPSC

12352005

Target

SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cleistanthin-b.html

Purity

98.19

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)=C2CO1

Molecular Formula

C27H26O12

Molecular Weight

542.49

References & Citations

[1]Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9 (3) :471.|[2]Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6 (4) :383-388.|[3]Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4 (2) :73-7.|[4]Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5 (4) :109-14.