XL388

XL388 is a highly potent and ATP-competitive mTOR inhibitor with an IC50 of 9.9 nM. XL388 simultaneously inhibits both mTORC1 and mTORC2.

Product Specifications

CAS Number

[1251156-08-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Autophagy; mTOR

Type

Reference compound

Related Pathways

Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xl388.html

Purity

99.74

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1CCOC2=CC=C(C3=CC=C(N)N=C3)C=C2C1)C4=CC=C(S(=O)(C)=O)C(F)=C4C

Molecular Formula

C23H22FN3O4S

Molecular Weight

455.50

Precautions

H315, H319, H335

References & Citations

[1]Takeuchi CS, et al. Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR) . J Med Chem. 2013 Mar 28;56 (6) :2218-34.|[2]Zhu YR, et al. The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models. Oncotarget. 2016 Aug 2;7 (31) :49527-49538.