Mdivi-1
Product Specifications
UNSPSC Description
Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.
Target Antigen
Apoptosis; Autophagy; Dynamin; Mitophagy
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Mdivi-1.html
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
O=C1N(C2=C(Cl)C=C(Cl)C(OC)=C2)C(S)=NC3=C1C=CC=C3
Molecular Weight
353.22
References & Citations
[1]Cassidy-Stone A, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb;14(2):193-204.|[2]Tanaka A, et al. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell. 2008 Feb 29;29(4):409-10.|[3]Park SW, et al. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011 Apr 27;52(5):2837-43.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15886/Mdivi-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15886/Mdivi-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
338967-87-6
Available Sizes
Curated Selection
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