MM41

MM41 is a quadruplex-interacting compound. MM41 binds tightly to quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes. MM41 reduces BCL-2 and k-RAS protein levels, increases caspase 3. MM41 has antitumor effects against pancreatic cancer[1].

Product Specifications

CAS Number

[1429028-96-5]

UNSPSC

12352005

Target

Bcl-2 Family; Caspase; G-quadruplex; Ras

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mm41.html

Purity

98.89

Solubility

DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 8 with HCl)

Smiles

O=C1C2=CC(NCCCN3CCN(CC3)C)=C4C(N(CCCN5CCOCC5)C(C6=CC(NCCCN7CCN(CC7)C)=C(C2=C64)C(N1CCCN8CCOCC8)=O)=O)=O

Molecular Formula

C44H66N10O6

Molecular Weight

831.06

References & Citations

[1]Ohnmacht SA, et al. A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer. Sci Rep. 2015 Jun 16;5:11385.