5-trans-PGE2

5-trans-PGE2 (5-trans Prostaglandin E2) is the active isomer of PGE2 and a potent activator of aromatase. Supplements the process of paracrine signaling between epithelial cells (expressing high levels of PGE2) and surrounding stromal cells (expressing high levels of aromatase) . This process is involved in the growth and development of breast cancer[1].

Product Specifications

CAS Number

[36150-00-2]

Product Name Alternative

5-trans Prostaglandin E2

UNSPSC

12352211

Hazard Statement

H302-H360

Target

Cytochrome P450; Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-trans-pge2.html

Solubility

10 mM in DMSO

Smiles

CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C/CCCC(O)=O

Molecular Formula

C20H32O5

Molecular Weight

352.47

Precautions

P264-P270-P280-P330-P405-P501

References & Citations

[1]Richards JA, et al. Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. J Clin Endocrinol Metab. 2003 Jun;88 (6) :2810-6.