MSC-1186

MSC-1186, a chemical probe, is a highly selective pan-SRPK inhibitor. MSC-1186 has activity for SRPK1, SRPK2 and SRPK3 with IC50 values of 2.7 nM, 81 nM and 0.6 nM, respectively. MSC-1186 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2871698-23-4]

UNSPSC

12352005

Target

SRPK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/msc-1186.html

Concentration

10mM

Purity

98.95

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CS(=O)(N(C1=NC=CC=C1CNC2=NC(C3=NC4=C(F)C(Cl)=CC=C4N3)=NC=C2)C)=O

Molecular Formula

C19H17ClFN7O2S

Molecular Weight

461.90

References & Citations

[1]Martin Schröder, et al. MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. J Med Chem. 2022 Dec 14.