MDM2-IN-26
MDM2-IN-26 (compound A3) is an MDM2 inhibitor that can activate the tumor suppressor function of p53 by blocking the interaction between MDM2 and p53 (MDM2 is the main negative regulator of p53) . MDM2-IN-26 can be used for cancer research[1].
Product Specifications
CAS Number
[1818393-11-1]
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mdm2-in-26.html
Solubility
10 mM in DMSO
Smiles
OC(C12CCC(CC2)(NC([C@H]3[C@H](C4=CC=CC(Cl)=C4F)[C@@]5(C(C=CC(Cl)=C6)=C6NC5=O)C7(CCC(F)(F)CC7)N3)=O)CC1)=O
Molecular Formula
C32H32Cl2F3N3O4
Molecular Weight
650.52
References & Citations
[1]Yifan Zhai, et al. MDM2 inhibitor and a platinum compound for cancer treatment. Patent US11850239B2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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APAF1 (Apoptotic Protease-activating Factor 1, APAF-1, KIAA0413) discontinued