DMT1 blocker 1
DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia[1].
Product Specifications
CAS Number
[1354790-56-9]
UNSPSC
12352005
Target
Ferroportin
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dmt1-blocker-1.html
Purity
99.79
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(C(NC2=CC=CC=C2)=O)C(C)=NN1C3=NC=CC=C3
Molecular Formula
C16H14N4O2
Molecular Weight
294.31
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
IFIT1 (Interferon-induced Protein with Tetratricopeptide Repeats 1, IFIT-1, Interferon-induced 56kD Protein, IFI-56K, P56, G10P1, IFI56, IFNAI1, ISG56) (MaxLight 650)
IFIT1 (Interferon-induced Protein with Tetratricopeptide Repeats 1, IFIT-1, Interferon-induced 56kD Protein, IFI-56K, P56, G10P1, IFI56, IFNAI1, ISG56) (MaxLight 650)
