DMT1 blocker 1

DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia[1].

Product Specifications

CAS Number

[1354790-56-9]

UNSPSC

12352005

Target

Ferroportin

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/dmt1-blocker-1.html

Purity

99.79

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C(C(NC2=CC=CC=C2)=O)C(C)=NN1C3=NC=CC=C3

Molecular Formula

C16H14N4O2

Molecular Weight

294.31

References & Citations

[1]Cadieux JA, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1) . Bioorg Med Chem Lett. 2012 Jan 1;22 (1) :90-5.