JAK-IN-14

JAK-IN-14 is a potent and selective JAK1 inhibitor, with an IC50 of 8-fold more selective for JAK1 than JAK2 and JAK3 (Patent WO2016119700A1, compound 16) [1].

Product Specifications

CAS Number

[1973485-06-1]

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jak-in-14.html

Concentration

10mM

Purity

99.15

Solubility

DMSO : 10.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#CCC1=CC(F)=C(C2=CC=CC3=NC(NC(C4CC4)=O)=CN32)C=C1

Molecular Formula

C19H15FN4O

Molecular Weight

334.35

References & Citations

[1]Jin Li, et al. Substituted imidazo [1, 2-a] pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof. WO2016119700A1.