JAK-IN-14
Product Specifications
UNSPSC Description
JAK-IN-14 is a potent and selective JAK1 inhibitor, with an IC50 of 8-fold more selective for JAK1 than JAK2 and JAK3 (Patent WO2016119700A1, compound 16)[1].
Target Antigen
JAK
Type
Reference compound
Related Pathways
Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak-in-14.html
Solubility
DMSO : 10.5 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
N#CCC1=CC(F)=C(C2=CC=CC3=NC(NC(C4CC4)=O)=CN32)C=C1
Molecular Weight
334.35
References & Citations
[1]Jin Li, et al. Substituted imidazo [1, 2-a] pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof. WO2016119700A1.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139807/JAK-IN-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139807/JAK-IN-14-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1973485-06-1
Available Sizes
Curated Selection
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