K-Ras-IN-3
K-Ras-IN-3 (compound 3) is a potent GDP-KRAS G12V inhibitor with an IC50 value of 0.371 nM. K-Ras-IN-3 has the potential for the research of cancer[1].
Product Specifications
CAS Number
3024991-82-7
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k-ras-in-3.html
Smiles
OC(C(F)(F)F)=O.CN([C@@H]1[C@H](C1)F)C2=NC(OCC34N(CCC4)CC(C3)=C)=NC5=C2C=NC(C6=CC(O)=CC7=C6C(C#C)=C(F)C=C7)=C5F
Molecular Formula
C34H29F6N5O4
Molecular Weight
685.62
References & Citations
[1]Robert B. Kargbo, et al. Innovative Therapeutic Approaches Targeting K-Ras: Analysis of Macrocyclic Compounds, Peptidomimetics, and Pyridopyrimidine Inhibitors, ACS Med. Chem. Lett. 2024, 15, 8, 1196-1198.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
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