BML-259
BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].
Product Specifications
CAS Number
267654-00-2
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bml-259.html
Concentration
10mM
Purity
99.12
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC=C(C(C)C)S1)CC2=CC=CC=C2
Molecular Formula
C14H16N2OS
Molecular Weight
260.35
Precautions
H315, H319, H335
References & Citations
[1]Kaźmierczak A, et al. A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5) . Neurochem Int. 2011;58 (2) :206-214.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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