LM22B-10

LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.

Product Specifications

CAS Number

[342777-54-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; ERK; Trk Receptor

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/LM22B-10.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C(C2=CC=C(N(CCO)CCO)C=C2)C3=CC=C(N(CCO)CCO)C=C3)C=C1

Molecular Formula

C27H33ClN2O4

Molecular Weight

485.01

Precautions

H302, H315, H319, H335

References & Citations

[1]Yang T, et al. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016 Nov;110 (Pt A) :343-61.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Akt; ERK; TrkB; TrkC

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP2-99732APC 0.1 mL

Rabbit Polyclonal CD39L4/ENTPD5 Antibody [Allophycocyanin]

Ask

View Details

bs-9368R-PerCP 100 µL

OCEL1 Polyclonal Antibody, PerCP Conjugated

Ask

View Details

GTR15371115 1 Vial

Lentiviral human SPATA2L sgRNA gene knockout kit - Lentiviral human SPATA2L sgRNA gene knockout kit (25)

Ask

View Details

NB100-61595R 0.1 mL

Rabbit Polyclonal CCDC99 Antibody [DyLight 550]

Ask

View Details