LM22B-10
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
Product Specifications
CAS Number
342777-54-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; ERK; Trk Receptor
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LM22B-10.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C(C2=CC=C(N(CCO)CCO)C=C2)C3=CC=C(N(CCO)CCO)C=C3)C=C1
Molecular Formula
C27H33ClN2O4
Molecular Weight
485.01
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang T, et al. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016 Nov;110 (Pt A) :343-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; ERK; TrkB; TrkC
Available Sizes
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