Ceefourin 1

Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma[1][2].

Product Specifications

CAS Number

[315702-40-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ceefourin-1.html

Purity

99.72

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

S=C1NN=C(CSC2=NC3=CC=CC=C3S2)N1C

Molecular Formula

C11H10N4S3

Molecular Weight

294.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Leanna Cheung, et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4) . Biochem Pharmacol. 2014 Sep 1;91 (1) :97-108.|[2]Tony Huynh, et al. CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth. Biochem Pharmacol. 2020 Feb;172:113770.