Lu AF58801
Product Specifications
UNSPSC Description
Lu AF58801 is a potent, orally available, brain-penetrant positive allosteric modulator of α7 nicotinic acetylcholine receptors with efficacy in a novel object recognition task in mice. Lu AF58801 was shown to selectively enhance the activity of α7 nicotinic acetylcholine receptors. Lu AF58801 was able to improve cognitive function in mice treated with subchronic fluchlorothiazol (PCP)[1].
Target Antigen
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lu-af58801.html
Smiles
OC[C@@H](C1=CC=C(C=C1)OCC)NC([C@@H]2[C@@H](C3=CC=CC=C3)C2)=O
Molecular Weight
325.40
References & Citations
[1]Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120783/Lu-AF58801-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120783/
Clinical Information
No Development Reported
CAS Number
1531592-40-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1351844-01 0.02 mg (E-Coli)
Recombinant Arabidopsis thaliana Dof zinc finger protein DOF5.7 (DOF5.7)
Ask
View Details MBS1351844-02 0.02 mg (Yeast)
Recombinant Arabidopsis thaliana Dof zinc finger protein DOF5.7 (DOF5.7)
Ask
View Details