Lu AF58801

Lu AF58801 is a potent, orally available, brain-penetrant positive allosteric modulator of α7 nicotinic acetylcholine receptors with efficacy in a novel object recognition task in mice. Lu AF58801 was shown to selectively enhance the activity of α7 nicotinic acetylcholine receptors. Lu AF58801 was able to improve cognitive function in mice treated with subchronic fluchlorothiazol (PCP) [1].

Product Specifications

CAS Number

[1531592-40-1]

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lu-af58801.html

Smiles

OC[C@@H](C1=CC=C(C=C1)OCC)NC([C@@H]2[C@@H](C3=CC=CC=C3)C2)=O

Molecular Formula

C20H23NO3

Molecular Weight

325.40

References & Citations

[1]Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP) -induced cognitive deficits in rats following oral administration