G-1

G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM.

Product Specifications

CAS Number

[881639-98-1]

UNSPSC

12352005

Hazard Statement

H302, H372, H400

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/G-1.html

Purity

99.76

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

BrC1=C([C@H]2[C@]3([H])[C@](C=CC3)([H])C4=CC(C(C)=O)=CC=C4N2)C=C5C(OCO5)=C1

Molecular Formula

C21H18BrNO3

Molecular Weight

412.28

Precautions

H302, H372, H400

References & Citations

[1]Cheng Q, et al. G-1 exerts neuroprotective effects through G protein-coupled estrogen receptor 1 following spinal cord injury in mice. Biosci Rep. 2016 Aug 31;36 (4) . pii: e00373.|[2]Kurt AH, et al. Oxidative/antioxidative enzyme-mediated antiproliferative and proapoptotic effects of the GPER1 agonist G-1 on lung cancer cells. Oncol Lett. 2015 Nov;10 (5) :3177-3182.|[3]Chimento A, et al. GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo. Oncotarget. 2015 Aug 7;6 (22) :19190-203.