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4-MU-α-GlcNS (sodium)

4-MU-α-GlcNS sodium is a fluorogenic substrate of heparin sulphamidase, is desulfurized into 4-MU-α-GlcNH2. 4-MU-α-GlcNH2 can liberate 4-methylumbelliferone (4-MU, fluorescent product) via α-glucosaminidase catalysis, with the emission wavelength maxima of 445-454 nm. 4-MU-α-GlcNS sodium can be used to heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders researches[1][2][3].

Product Specifications

CAS Number

460085-45-4

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/4-mu-α-glcns-sodium.html

Purity

99.81

Solubility

DMSO : 4.39 mg/mL (ultrasonic; warming)

Smiles

O=S(N[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O)[C@H]1OC2=CC=C(C(C)=CC(O3)=O)C3=C2)(O[Na])=O

Molecular Formula

C16H18NNaO10S

Molecular Weight

439.37

References & Citations

[1]Karpova EA, et al. A fluorimetric enzyme assay for the diagnosis of Sanfilippo disease type A (MPS IIIA) . J Inherit Metab Dis. 1996;19 (3) :278-85. |[2]Dasgupta F, et al. Synthesis of 7-O- (2-deoxy-2-sulfamido-alpha-D-glucopyranosyl) -4-methylcoumarin sodium salt: a fluorogenic substrate for sulfamidase. Carbohydr Res. 2002 Jun 5;337 (11) :1055-8. |[3]G. Civallero, et al. Assay of heparan-N-sulfamidase in dried leukocytes impregnated in filter paper: A new tool for the identification of Mucopolisaccharidosis IIIA and potentially other lysosomal disorders, Molecular Genetics and Metabolism. 2013;108 (4) : 267-268.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Frequently Asked Questions

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