BRL 52537 (hydrochloride)
BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with Kis of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage[1].
Product Specifications
CAS Number
112282-24-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/brl-52537-hydrochloride.html
Purity
98.14
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : 25 mg/mL (ultrasonic)
Smiles
O=C(CC1=CC=C(C(Cl)=C1)Cl)N2CCCCC2CN3CCCC3.Cl
Molecular Formula
C18H25Cl3N2O
Molecular Weight
391.76
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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