BRL 52537 (hydrochloride)

BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with Kis of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage[1].

Product Specifications

CAS Number

[112282-24-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/brl-52537-hydrochloride.html

Purity

98.14

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : 25 mg/mL (ultrasonic)

Smiles

O=C(CC1=CC=C(C(Cl)=C1)Cl)N2CCCCC2CN3CCCC3.Cl

Molecular Formula

C18H25Cl3N2O

Molecular Weight

391.76

Precautions

H315, H319, H335

References & Citations

[1]Toru Goyagi, et al. Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats. Stroke. 2003 Jun;34 (6) :1533-8.