Anti-Acetylated Lysine Antibody
Mouse Monoclonal Antibody specific to Acetylated Lysine
Product Specifications
Product Name Alternative
Anti-Acetylated Lysine Mouse Monoclonal Antibody
Host
Mouse
Reactivity
All
Immunogen
Acetylated KLH
Target
Acetylated Lysine
Clonality
Monoclonal
Isotype
IgG1
Type
Antibody
Applications
WB, IHC, ICC/IF, IP, ELISA
Field of Research
Neuroscience
Purification Method
Purified by Protein G affinity chromatography
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Format
Purified
Form
Liquid
Buffer
Phosphate Buffered Saline
Additionnal Information
Immunoblotting: use at 1ug/mL.
<br><br>These are recommended concentrations. User should determine optimal concentrations for their application.
<br><br>Positive control: Acetylated chicken erythrocyte histones.
Storage Conditions
This antibody is stable for at least one (1) year at -20°C.
Product Datasheet
https://www.qedbio.com/wp-content/uploads/pdf/56455.pdf
Specificity
This antibody recognizes proteins containing acetylated lysine residues. It does not react with non-acetylated lysine residues.
Formulation
PBS, pH 7.4.
Buffer pH
pH 7.4
Target Background
Acetylation is a common post-translational modification of lysine. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Post- translational acetylation and deacetylation of lysine have been recognized as intracellular signals that are critical in regulating gene transcription, cell cycle progression, apoptosis, DNA repair, and cytoskeletal organization. Regulation of protein acetylation is impaired in some cancers and polyglutamine diseases, and HDACs are promising targets for anti-cancer drugs currently under investigation.
CAS Number
9007-83-4
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