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L57

L57 is a Low-density lipoprotein receptor-related protein 1 (LRP1) -binding peptide. L57 exhibits high affinity to LRP1 with a Ki of 45 nM. L57 exhibits blood-brain barrier (BBB) permeability and plasma stability. L57 can be utilized as the carrier for CNS drug delivery[1].

Product Specifications

CAS Number

[2378836-93-0]

UNSPSC

12352209

Target

LDLR

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/l57.html

Smiles

O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CNC=N6)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC9=CNC=N9)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

Molecular Formula

C120H175N31O27

Molecular Weight

2483.87

References & Citations

[1]Sakamoto K, et al., A novel LRP1-binding peptide L57 that crosses the blood brain barrier. Biochem Biophys Rep. 2017 Aug 12;12:135-139.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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