3β,7β-Dihydroxy-5-cholestenoic acid
3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid that displays elevated levels in Niemann-Pick type C and Niemann-Pick type B diseases, contributing to toxicity in oculomotor neurons. It is synthesized from 3β-hydroxy-7-oxocholest-5-en- (25R) 26-oic acid (3βH,7O-CA) through the enzymatic action of hydroxysteroid 11-β dehydrogenase 1.
Product Specifications
CAS Number
[1246298-66-7]
UNSPSC
12352211
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/3β-7β-dihydroxy-5-cholestenoic-acid.html
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC[C@@H](C)C(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=C[C@@H]3O)C
Molecular Formula
C27H44O4
Molecular Weight
432.64
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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