MK-0493 (hydrochloride)
Product Specifications
UNSPSC Description
MK-0493 hydrochloride is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake[1].
Target Antigen
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mk-0493-hydrochloride.html
Purity
98.76
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CC(N[C@H](C1=CC(Cl)=CC=C1C2CCN(C([C@@H]3CN(C(C)(C)C)C[C@H]3C4=CC=C(F)C=C4F)=O)CC2)C)=O.[H]Cl
Molecular Weight
582.55
References & Citations
[1]Krishna R, etal. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther. 2009 Dec;86(6):659-66.|[2]Sezen SF, et al. Intracavernosal pressure monitoring in mice: responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration. J Androl. 2000 Mar-Apr;21(2):311-5.|[3]Hong Q, et al. Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2330-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118930A/MK-0493-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118930A/MK-0493-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
455957-71-8
Available Sizes
Curated Selection
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