Plixorafenib
PLX8394 is a potent and selective BRaf inhibitor, with an IC50 of appr 5 nM for BRAFV600E.
Product Specifications
CAS Number
1393466-87-9
Product Name Alternative
PLX8394; FORE8394
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PLX8394.html
Purity
99.80
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(F)C(NS(=O)(N2CC[C@@H](F)C2)=O)=CC=C1F)C3=CNC4=C3C=C(C=N4)C5=CN=C(C6CC6)N=C5
Molecular Formula
C25H21F3N6O3S
Molecular Weight
542.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Basile KJ, et al. Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors. Pigment Cell Melanoma Res. 2014 May;27 (3) :479-484.|[2]Okimoto RA, et al. Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer. Proc Natl Acad Sci U S A. 2016 Nov 22;113 (47) :13456-13461
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
B-Raf
Available Sizes
Frequently Asked Questions
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