Plixorafenib

PLX8394 is a potent and selective BRaf inhibitor, with an IC50 of appr 5 nM for BRAFV600E.

Product Specifications

CAS Number

[1393466-87-9]

Product Name Alternative

PLX8394; FORE8394

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PLX8394.html

Purity

99.80

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=C(F)C(NS(=O)(N2CC[C@@H](F)C2)=O)=CC=C1F)C3=CNC4=C3C=C(C=N4)C5=CN=C(C6CC6)N=C5

Molecular Formula

C25H21F3N6O3S

Molecular Weight

542.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Basile KJ, et al. Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors. Pigment Cell Melanoma Res. 2014 May;27 (3) :479-484.|[2]Okimoto RA, et al. Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer. Proc Natl Acad Sci U S A. 2016 Nov 22;113 (47) :13456-13461