5-LOX-IN-6
5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO) . 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research[1].
Product Specifications
CAS Number
1159576-98-3
UNSPSC
12352005
Target
Leukotriene Receptor; Lipoxygenase
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/5-lox-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(CC2=CC(Cl)=CC=C2)NC3=C1C=C(C4=C3C=CC=C4)O)OCC
Molecular Formula
C22H18ClNO3
Molecular Weight
379.84
References & Citations
[1]Karg EM, et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem. 2009 Jun 11;52 (11) :3474-83.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX; LTB4
Available Sizes
Frequently Asked Questions
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