Src (phospho-Ser17) rabbit pAb

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

P12931

Swiss Prot

P12931

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized phosho peptide around human Src (Ser17)

Clonality

Polyclonal

Source

Rabbit

Applications

Concentration

1 mg/ml

Dilution

WB 1:1000-2000

Molecular Weight

60kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

60kD

Fragment

IgG

Subcellular Location

Cell membrane ; Lipid-anchor . Mitochondrion inner membrane . Nucleus . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell junction, focal adhesion . Localizes to focal adhesion sites following integrin engagement (PubMed:22801373) . Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268) . Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596) . .