Butyrolactone I
Butyrolactone I is an orally active and ATP-competitive inhibitor of CDK1. Butyrolactone I inhibits NF-κB, cdc2 kinase, Bax, ROS production, modulates the PERK/CHOP. Butyrolactone I mitigates heat-stress-induced Apoptosis. Butyrolactone I shows anti-inflammatory and intestinal protective activity. Butyrolactone I has antitumor effects against non-small cell lung, small cell lung, prostate cancer and leukemia. Butyrolactone I can be used in NASH research[1][2][3][4][5][6][7].
Product Specifications
CAS Number
87414-49-1
Product Name Alternative
Olomoucin
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Bcl-2 Family; CDK; NF-κB; PERK; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/butyrolactone-i.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC([C@]1(C(C2=CC=C(C=C2)O)=C(C(O1)=O)O)CC3=CC(C/C=C(C)\C)=C(C=C3)O)=O
Molecular Formula
C24H24O7
Molecular Weight
424.44
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Fast Plus EvaGreen® qPCR Master Mix (trial size, 100 rxn)
