BMS-466442

BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research[1][2].

Product Specifications

CAS Number

[1598424-76-0]

UNSPSC

12352005

Target

Adrenergic Receptor; ASCT; Dopamine Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bms-466442.html

Purity

98.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](CC1=CN(C=N1)CC2=CC=CC=C2)NC(C3=CC4=C(C=C(C(OC)=C4)OCC5=CC=CC=C5)N3)=O)OC

Molecular Formula

C31H30N4O5

Molecular Weight

538.59

References & Citations

[1]Brown JM, et al. In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10) . J Neurochem. 2014 Apr;129 (2) :275-83.|[2]Torrecillas IR, et al. Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442. ACS Chem Neurosci. 2019 May 15;10 (5) :2510-2517.