BMS-466442
Product Specifications
UNSPSC Description
BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research[1][2].
Target Antigen
Adrenergic Receptor; ASCT; Dopamine Transporter
Type
Reference compound
Related Pathways
GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bms-466442.html
Purity
98.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H](CC1=CN(C=N1)CC2=CC=CC=C2)NC(C3=CC4=C(C=C(C(OC)=C4)OCC5=CC=CC=C5)N3)=O)OC
Molecular Weight
538.59
References & Citations
[1]Brown JM, et al. In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J Neurochem. 2014 Apr;129(2):275-83.|[2]Torrecillas IR, et al. Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442. ACS Chem Neurosci. 2019 May 15;10(5):2510-2517.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120170/BMS-466442-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120170/BMS-466442-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1598424-76-0
Available Sizes
Curated Selection
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