AFP464 (dihydrochloride)

AFP464 (dihydrochloride) (NSC710464 (dihydrochloride) ) is the hydrochloride form of AFP464 and is a potent HIF-1α inhibitor with an IC50 value of 0.25 μM. It is also an activator of aryl hydrocarbon receptor (AhR) .

Product Specifications

Product Name Alternative

NSC710464 (dihydrochloride)

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/afp464-dihydrochloride.html

Purity

99.67

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=C(C2=CC(C3=C(N)C(F)=C(C)C(F)=C3O2)=O)C=C1F)[C@@H](N)CCCCN.[H]Cl.[H]Cl

Molecular Formula

C22H25Cl2F3N4O3

Molecular Weight

521.36

References & Citations

[1]Terzuoli E1, Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep 1;70 (17) :6837-48.