KRASG12D-IN-1
KRASG12D-IN-1 (compound 22) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition[1].
Product Specifications
UNSPSC
12352005
Target
Ras
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.07
Solubility
DMSO : 71.43 mg/mL (ultrasonic)
Smiles
FC1=C(C2=CN=C1C3=C4C(C#C)=C(C=CC4=CC(O)=C3)F)N=C(N=C2N5C[C@H](CC6)N[C@H]6C5)OC([2H])(C78CCCN7C/C(C8)=C(F)\F)[2H]
Molecular Formula
C34H28D2F4N6O2
Molecular Weight
632.65
References & Citations
[1]Xiao X, et al. Design, Synthesis, and Pharmacological Evaluation of Multisubstituted Pyrido[4,3-d]pyrimidine Analogues Bearing Deuterated Methylene Linkers as Potent KRASG12D Inhibitors. J Med Chem. 2023 Nov 3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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