Costunolide

Costunolide ((+) -Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells[1][2][3].

Product Specifications

CAS Number

553-21-9

Product Name Alternative

(+) -Costunolide; Costus lactone

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H335

Target

Apoptosis; Endogenous Metabolite

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Costunolide.html

Purity

99.69

Solubility

DMSO : 233.33 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O[C@@]1([H])[C@@]2([H])CC/C(C)=C/CC/C(C)=C/1)C2=C

Molecular Formula

C15H20O2

Molecular Weight

232.32

Precautions

H315, H317, H319, H335

References & Citations

[1]Dae Yong Kim, et al. Costunolide-A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential. Int J Mol Sci. 2019 Jun; 20 (12) : 2926.|[2]Minyan Wei, et al. Costunolide induces apoptosis and inhibits migration and invasion in H1299 lung cancer cells. Oncol Rep. 2020 Jun;43 (6) :1986-1994.|[3]Zhangxiao Peng, et al. Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway.Sci Rep. 2017; 7: 41254.