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H-9 (Dihydrochloride)

H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor) -dependent epithelial cell lines[1][2][3].

Product Specifications

CAS Number

116700-36-8

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

5-HT Receptor; EGFR; PKA

Type

Reference compound

Related Pathways

GPCR/G Protein; JAK/STAT Signaling; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/h-9-dihydrochloride.html

Purity

98.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=CC2=C1C=CN=C2)(NCCN)=O.[H]Cl.[H]Cl

Molecular Formula

C11H15Cl2N3O2S

Molecular Weight

324.23

Precautions

H315, H319, H320

References & Citations

[1]Ito M, et al. A potent inhibitor of protein kinase C inhibits natural killer activity. Int J Immunopharmacol. 1988;10 (3) :211-6. |[2]Vázquez-López A, et al. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochem Res. 2005 May;30 (5) :613-8. |[3]Wollina U, et al. Inhibition of signal transduction in EGF-dependent epithelial cell lines. Int J Mol Med. 2003 Oct;12 (4) :673-7.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT Receptor

Available Sizes

Frequently Asked Questions

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