DMX-5804

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96) . DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1].

Product Specifications

CAS Number

[2306178-56-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/DMX-5804.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC=NC2=C1C(C3=CC=C(OCCOC)C=C3)=CN2C4=CC=CC=C4

Molecular Formula

C21H19N3O3

Molecular Weight

361.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Fiedler LR, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909 (19) 30013-X.