CP94253 (hydrochloride)

CP94253 hydrochloride is a potent and selective agonist of 5-HT1B receptor (Ki= 2 nM in a radioligand binding assay) .Ki values for 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors are 89, 49, 860, and 1600 nM respectively[1]. CP94253 hydrochloride is centrally active upon systemic administration in vivo[2].

Product Specifications

CAS Number

[845861-39-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cp94253-hydrochloride.html

Concentration

10mM

Purity

98.84

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CCCOC1=CC=C(NC=C2C3=CCNCC3)C2=N1.[H]Cl

Molecular Formula

C15H20ClN3O

Molecular Weight

293.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Dev.Res. 26 241 |[2]Knobelman DA, Kung HF, Lucki I. Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT (1A) and 5-HT (1B) receptors. J Pharmacol Exp Ther. 2000 Mar;292 (3) :1111-7