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Propargyl-PEG3-acid

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1]. Propargyl-PEG3-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

1347760-82-0

UNSPSC

12352203

Hazard Statement

H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/propargyl-peg3-acid.html

Purity

99.14

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CCOCCOCCOCC#C

Molecular Formula

C10H16O5

Molecular Weight

216.23

Precautions

H315, H319, H335

References & Citations

[1]Farzam A, et al. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biol. 2020 Jan;28:101377.|[2]Albone, Earl F, et al. ERIBULIN-BASED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE. Patent. 20170252458.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Non-cleavable Linker; PEG Linkers

Available Sizes

Frequently Asked Questions

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