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ζ-Stat (trisodium)

ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].

Product Specifications

CAS Number

[31894-34-5]

Product Name Alternative

NSC37044 (trisodium)

UNSPSC

12352005

Target

Apoptosis; PKC

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ζ-stat-trisodium.html

Purity

97.0

Solubility

H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=S(C1=C2C(O)=CC(S(=O)(O[Na])=O)=CC2=CC(S(=O)(O[Na])=O)=C1)(O[Na])=O

Molecular Formula

C10H5Na3O10S3

Molecular Weight

450.31

References & Citations

[1]Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12 (5) :447-463.|[2]Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-123979A/ζ-Stat-trisodium-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-123979A/ζ-Stat-trisodium-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PKCζ

Available Sizes

Curated Selection

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