ζ-Stat (trisodium)
Product Specifications
Product Name Alternative
NSC37044 (trisodium)
UNSPSC Description
ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].
Target Antigen
Apoptosis; PKC
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics;TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ζ-stat-trisodium.html
Purity
97.0
Solubility
H2O : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=S(C1=C2C(O)=CC(S(=O)(O[Na])=O)=CC2=CC(S(=O)(O[Na])=O)=C1)(O[Na])=O
Molecular Weight
450.31
References & Citations
[1]Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463.|[2]Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123979A/ζ-Stat-trisodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123979A/ζ-Stat-trisodium-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
31894-34-5
Available Sizes
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