NNC 55-0396

NNC 55-0396 is a highly selective T-type calcium channel blocker with an IC50 value of 6.8 μM for Cav3.1 T-type channels. NNC 55-0396 can be used for the research of neurological disease research[1][2].

Product Specifications

CAS Number

[357400-13-6]

Product Name Alternative

NNC 55-0396 dihydrochloride

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nnc-55-0396.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

O=C(C1CC1)O[C@@]2(CCN(CCCC3=NC4=CC=CC=C4N3)C)[C@@H](C(C)C)C5=C(C=C(F)C=C5)CC2.[H]Cl.[H]Cl

Molecular Formula

C30H40Cl2FN3O2

Molecular Weight

564.56

References & Citations

[1]Arnulfo Quesadaa, Peter H. Bui, Gregg E. Homanics, et al. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology. 2011,659 (1) : 30-36.|[2]Hideto Miwa, Jinsoo Koh, Yoshinori Kajimoto, et al. Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. Pharmacology Biochemistry and Behavior. 2011,97 (4) : 656-659.|[3]Huang L, Keyser BM, Tagmose TM, et al. NNC 55-0396 [ (1S,2S) -2- (2- (N-[ (3-benzimidazol-2-yl) propyl]-N-methylamino) ethyl) -6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004 Apr;309 (1) :193-9.