Aclerastide

Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers[1][2].

Product Specifications

CAS Number

[227803-63-6]

Product Name Alternative

DSC-127; NorLeu3-A (1-7)

UNSPSC

12352209

Target

Angiotensin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aclerastide.html

Purity

99.62

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H](CCCC)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(O)=O)=O)=O)=O

Molecular Formula

C42H64N12O11

Molecular Weight

913.03

References & Citations

[1]Kathleen E Rodgers, et al. Acceleration of healing, reduction of fibrotic scar, and normalization of tissue architecture by an angiotensin analogue, NorLeu3-A (1-7) . Plast Reconstr Surg. 2003 Mar;111 (3) :1195-206.|[2]Trung T Nguyen, et al. Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. Eur J Pharmacol. 2018 Sep 5;834:77-83.