Gamma-Mangostin

Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes[1][2][3][4][5].

[1]Chairungsrilerd N, et al. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):25-31.|[2]Yokoyama T, et al. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570.|[3]Husen S A, et al. Hepatoprotective Effect of Gamma-mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-induced Diabetic Mice. 2018 IOP Conf. Ser.: Earth Environ. Sci. 217 012031|[4]Husen S A, et al. Renal protective effects of gamma-mangostin in streptozotocin-induced diabetic mice[J]. Indian Journal of Forensic Medicine & Toxicology, 2020, 14(3): 1251-1256.|[5]Chen, S P, Lue, et al.Gamma-mangostin of Garcinia mangostana peels ameliorates hyperglycemia in synergism of insulin. The FASEB Journal, 33: 694.11-694.11.