R-7050
Product Specifications
UNSPSC Description
R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
Target Antigen
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/R-7050.html
Purity
98.55
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
FC(F)(C1=NN=C2N1C3=CC(Cl)=CC=C3N=C2SC4=CC=CC=C4)F
Molecular Weight
380.77
References & Citations
[1]Gururaja TL, et al. A class of small molecules that inhibit TNFalpha-induced survival and death pathways viaprevention of interactions between TNFalphaRI, TRADD, and RIP1. Chem Biol. 2007 Oct;14(10):1105-18.|[2]King MD, et al. TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebralhemorrhage in mice. Neurosci Lett. 2013 May 10;542:92-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-110203/R-7050-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-110203/R-7050-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
303997-35-5
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7014932-01 0.02 mg
Recombinant Drosophila ananassae Calcium channel flower (flower)
Ask
View Details MBS7014932-02 0.1 mg
Recombinant Drosophila ananassae Calcium channel flower (flower)
Ask
View Details MBS7014932-03 5x 0.1 mg
Recombinant Drosophila ananassae Calcium channel flower (flower)
Ask
View Details ARP34424_T100-HRP 100 µL
TRIM10 Antibody - C-terminal region: HRP (ARP34424_T100-HRP)
Ask
View Details